Publications
Check Google Scholar or Pubmed for the updated list of publications.
2024
Brenzinger S, Airoldi M, Ogunleye AJ, Jugovic K, Amstalden MK, and Brochado AR. "The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibiotics". Nature Microbiology 2024. DOI: 10.1038/s41564-023-01556-y
Olayo-Alarcon R, Amstalden MK, Zannoni A, Bajramovic M, Sharma CM, Brochado AR, Rezaei M, Müller CL. Pre-trained molecular representations enable antimicrobial discovery. Preprint. bioRxiv 2024. doi: https://doi.org/10.1101/2024.03.11.584456
2023
Cacace E, Kim V,... Brochado AR... Typas A."Systematic analysis of drug combinations against Gram-positive bacteria". Nature Microbiology 2023. DOI: 10.1038/s41564-023-01486-9
Garcia-Santamarina S, Kuhn M... Brochado AR... Typas A. "Emergence of community behaviors in the gut microbiota upon drug treatment". Preprint bioRxiv 2023. doi: https://doi.org/10.1101/2023.06.13.544832
2021
Klünemann, M., Andrejev, S., Blasche, S.... Brochado AR ... Patil KR.. “Bioaccumulation of therapeutic drugs by human gut bacteria“. Nature 2021. DOI: 10.1038/s41586-021-03891-8.
2020
Domenech A, Brochado AR, Sender V, Hentrich K, Henriques-Normark B, Typas A and Veening JW. “Proton Motive Force Disruptors Block Bacterial Competence and Horizontal Gene Transfer“. Cell Host & Microbe 2020. DOI: 10.1016/j.chom.2020.02.002.
2019
Foerster S, Gustafsson TN... Brochado AR... Unemo M. "The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs". APMIS 2019. DOI: 10.1111/apm.1301
2018
Brochado AR, Telzerow A, Bobonis J, Banzhaf M, Mateus A, Selkrig J, Huth E, Bassler S, Zamarreño Beas J, Zietek M,Ng N, Foerster S, Ezraty B, Py B, Barras F, Savitski MM, Bork P, Göttig S and Typas A. “Species-specific activity of antibacterial drug combinations“. Nature 2018. DOI: 10.1038/s41586-018-0278-9.
Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A. “Extensive impact of non-antibiotic drugs on human gut bacteria”. Nature 2018. DOI: 555(7698) p.634-628.
Until 2018
Brochado AR & Patil KR. "Model-guided identification of gene deletion targets for metabolic engineering in Saccharomyces cerevisiae”. Yeast Metabolic Engineering: Methods and Protocols, Springer 2014, 281-291.
Ezraty B, Vergnes A, Banzhaf M, Duverger Y, Huguenot A, Brochado AR, et al. “Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway”. Science 2013. 340(6140) p.1583-1587.
Brochado AR and Typas A. “High-throughput approaches to understanding gene function and mapping network architecture in bacteria”. Current Opinion in Microbiology 2013. 16(2) p.199-206.
Brochado AR and Patil KR. “Overexpression of O-methyltransferase leads to improved vanillin production in baker's yeast only when complemented with model-guided network engineering”. Biotechnology and Bioengineering 2013. 110(2) p656-659.
Brochado AR, Andrejev S, Maranas CD and Patil KR. “Impact of Stoichiometry Representation on Simulation of Genotype-Phenotype Relationships in Metabolic Networks”. PloS Computational Biology 2012. DOI: 10.1371/journal.pcbi.1002758.
Brochado AR, Matos C, Møller BL, Hansen J, Mortensen UH, Patil KR. “Improved vanillin production in baker’s yeast through in silico design”. Microbial Cell Factories 2010. 9:84