I'm Susanne Brenzinger, a Postdoc in the lab.

About me

I am interested in bacterial cell physiology and how bacteria experience and respond to environmental cues. For my PhD thesis I studied bacterial motility, chemotaxis, and cell polarity in the lab of Prof. Kai Thormann at the Max Planck Institute for terrestrial Microbiology, Marburg (since 2013 at the University of Giessen, Germany). Following this, I joined the lab of Prof. Ariane Briegel at Leiden University (Netherlands) from 2017-2020 as a postdoctoral fellow, funded by the German National Academy of Science Leopoldina. Here, I studied how Vibrio cholerae copes with environmental stresses using cryo-electron tomography. Now, in the Brochado lab, I have the opportunity to continue to study the impact of environmental challenges on bacterial behaviour using high-throughput approaches. 

My project

I will explore how a plethora of chemical cues influence the regulation of particular stress response networks of Salmonella enterica serovar Typhimurium, and their consequences for virulence and antibiotic sensitivity. This project is funded by the bayresq.net and will be done in collaboration with Prof. Cynthia Sharma (JMU Würzburg) and Prof. Christian Müller (LMU Munich).

 

Publications

  • Brenzinger S, Van der Aart LT, Van Wezel GP, Lacroix J-M, Glatter T, Briegel, A. (2019) Structural and proteomic changes in viable but non-culturable Vibrio cholerae. Front Microbiol. 2019 Apr 17; 10:793. 

  • Ferreira, JL, Gao, FZ, Rossmann, FM, Nans, A, Brenzinger, S, Hosseini, R, Wilson A, Briegel A, Thormann KM, Rosenthal PB, Beeby, M. (2019). γ-proteobacteria eject their polar flagella under nutrient depletion, retaining flagellar motor relic structures. PLOS Biology, 17(3), e3000165. 

  • Brenzinger S, Pecina A, Mrusek D, Mann P, Völse K, Wimmi S, Ruppert U, Becker A, Ringgaard S, Bange G, Thormann KM. (2018) ZomB is essential for flagellar motor reversals in Shewanella putrefaciens and Vibrio parahaemolyticus. Mol Microbiol. 2018 Sep;109(5):694-709. 

  • Ultee E, Schenkel F, Yang W, Brenzinger S, Depelteau JS, Briegel A. (2018) An Open-Source Storage Solution for Cryo-Electron Microscopy Samples. Microsc Microanal. 2018 Feb;24(1):60-63. 

  • Brenzinger S, Dewenter L, Delalez NJ, Leicht O, Berndt V, Berry RM, Thanbichler M, Armitage JP, Maier B, Thormann KM. (2016) Mutations targeting the plug-domain of the Shewanella oneidensis proton-driven stator allow swimming at increased viscosity and under anaerobic conditions. Mol Microbiol. 2016 Dec;102(5):925-938. 

  • Dwarakanath S, Brenzinger S, Gleditzsch D, Plagens A, Klingl A, Thormann KM, Randau L. (2015) Interference activity of a minimal Type I CRISPR-Cas system from Shewanella putrefaciens. Nucleic Acids Res. 2015 Oct 15;43(18):8913-23. 

  • Brenzinger S, Rossmann F, Knauer C, Dörrich AK, Bubendorfer S, Ruppert U, Bange G, Thormann KM. (2015) The role of FlhF and HubP as polar landmark proteins in Shewanella putrefaciens CN-32. Mol Microbiol. 2015 Nov;98(4):727-42. 

  • Paulick A, Delalez NJ, Brenzinger S, Steel BC, Berry RM, Armitage JP, Thormann KM. (2015) Dual stator dynamics in the Shewanella oneidensis MR-1 flagellar motor. Mol Microbiol. 2015 Jun;96(5):993-1001. 

  • Bubendorfer S, Held S, Windel N, Paulick A, Klingl A, Thormann KM. (2012) Specificity of motor components in the dual flagellar system of Shewanella putrefaciens CN-32. Mol Microbiol. 2012 Jan;83(2):335-50. 

  • Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. (2011), Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell. 2011 May 13;145(4):513-28. 

  • Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, Coene KL, Estrada-Cuzcano A, Collin RW, McLaughlin HM, Held S, …, Hildebrandt F. (2010) Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet. 2010 Oct;42(10):840-50. 

 

Visit

Würzburg University,

Biocenter, Chair of Microbiology

Am Hubland, 97074 Würzburg,

Germany

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Ana Rita Brochado

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